Poster #097, University of California, Riverside
Wireless Neuromodulation in Parkinson’s Disease via Mechanoluminescent Mn-Doped ZnS Nanoparticles
Mentor: Allison Sander (Grad Student), Anannya Khanna (Grad Student), Karla Rodriguez Pequeno (Grad Student); PI: Huinan Liu, PhD
As Parkinson’s Disease progresses, the deterioration of brain cells accelerates, producing symptoms such as impaired motor skills. Currently, these symptoms are managed through Deep Brain Stimulation, an invasive surgery requiring the implantation of permanent hardware. Mechanoluminescent Mn-doped ZnS nanoparticles could offer a better approach for managing these symptoms by removing the need for invasive treatment. Mn-doped ZnS nanoparticles are ideal because their luminescent properties allow them to act as energy translators, converting mechanical energy into local electrical signals which stimulate neural stem cell neurogenesis. This promotes the cells’ differentiation into healthy dopaminergic neurons, triggering integration into the existing brain circuit and replicating healthy network activity. In this project, Mn-doped ZnS nanoparticles were synthesized by dissolving aqueous precursors and combining them with ethylene glycol and water and sealing the mixture in a hydrothermal unit. Future work could include coupling these nanoparticles with externally applied ultrasound to enable wireless cellular neuromodulation, as well as developing surface modification strategies to enhance Blood-Brain Barrier penetration and brain-targeted delivery. Ultimately, this approach offers an accessible and non-invasive alternative to open brain surgery for patients with Parkinson’s.