Mammoth Biosciences is Rewriting the Code of Life to Unlock the True Potential of Genetic Medicine
When it comes to CRISPR-based gene therapies, size isn’t just a detail—it’s a game-changer. Traditional gene editing relies on the Cas9 enzyme, a powerful tool but one with delivery and targeting challenges. Mammoth Biosciences is rewriting the rules with ultracompact Cas enzymes, enabling more precise in-vivo delivery, even in hard-to-reach tissues.
Through partnerships with Vertex, Bayer and Regeneron, Mammoth is expanding its pipeline with next-generation techniques like base editing, reverse transcriptase editing, and epigenetic editing. Co-founded by CRISPR pioneer and Nobel laureate Jennifer Doudna, Ph.D., the company is moving beyond traditional gene splicing to develop more precise, controlled, and potentially safer therapies.
Located in Brisbane—just south of South San Francisco—Mammoth thrives at the intersection of research and industry. With strong ties to UC Berkeley and access to the Bay Area’s deep scientific talent, the company is fueled by a culture of innovation and entrepreneurship. The region’s venture capital network ensures that breakthrough ideas are brought to life.
As in-vivo therapies redefine genetic medicine, Mammoth is pioneering next-generation gene-editing technologies to enable powerful, accessible treatments for genetic disease patients worldwide.
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