Poster #085
Synthesis of HA Nanoparticles for Future Use in Diabetic Wound Dressings
Mentors: Allison Sander (Grad Student), Karla Rodriguez Pequeno (Grad Student), PI: Huinan Liu PhD
Chronic diabetic wounds remain one of the most challenging complications in regenerative medicine, often resisting traditional treatments due to poor circulation and impaired healing. Modified HA NPs via metal doping or composite fabrication are known for their biocompatibility and ability to release calcium and phosphate ions that promote angiogenesis, cell growth, and extracellular matrix formation, processes critical for effective wound repair. To address this, hydroxyapatite nanoparticles (HA NPs) were synthesized using a wet-chemical synthesis method followed by hydrothermal treatment. With further development, these nanoparticles may be integrated into biodegradable dressings to support localized, sustained healing in diabetic ulcers. The inclusion of platelet-derived growth factor (PDGF) could further strengthen therapeutic effects by promoting cell recruitment and accelerating tissue regeneration. This synthesis lays the groundwork for future mineral-based wound therapies designed to move beyond passive protection and actively support regeneration in compromised tissue environments.