Poster #074
How does LPS affect the ECM in the small intestine?
Mentors: Cray Minor, BS and Kevin Tharp, PhD
Bacterial Lippopolysacharride is an immune recognized pathogenic associated molecular pattern that can activate immune responses. In acute cases of bacterial infection of the small intestine, LPS can disrupt the functions of tight junctions, prompting an immune response to reduce risk to surrounding tissues. Collagen can act as a physical barrier to prevent bacterial spread, and provides vital rigidity to the small intestine. Collagen also provides essential nutrients to immune cells for a more robust immune response. In tissue sections of LPS exposed samples, collagen decreased when compared to non exposed tissues. This poster further explores how LPS responses affect small intestinal structures and permeability.